Dopamine related disorders: new models and prospective therapeutic approaches

Dr. Damiana Leo

Department of Neuroscience, University of Mons, Belgium

The dopamine transporter (DAT) is a presynaptic monoamine transporter that mediates dopamine reuptake at the synapse and is subjected to short- and long-term regulation by multiple drugs and physiological processes. Further, mutations in the gene encoding the DAT protein (SLC6A3) can lead to severe neuropsychiatric diseases. Despite decades of studies describing the role of DAT, whether the influence of the DAT goes beyond the reuptake of dopamine is still a matter of debate.

Here, we present a newly developed strain of rats in which the gene encoding the dopamine transporter (DAT) has been disrupted (Dopamine Transporter Knockout rats [DAT-KO rats]). DAT-KO rats display functional hyperdopaminergia accompanied by pronounced spontaneous locomotor hyperactivity. DAT-KO rats also demonstrate cognitive deficits in working memory and sensorimotor gating test.

These observations highlight the key role of DAT in the control of brain dopaminergic transmission. DAT-KO rats could provide a novel translational model for human diseases involving aberrant dopamine functions such as Attention Deficit with Hyperkinetic disorders, Dopamine Transporter Deficiency Syndrome, Parkinson's disease and partly bipolar disorders.

Il seminario si terrà in forma di webinar :

https://global.gotomeeting.com/join/992976373

Contact: Dr Elia Di Schiavi

e-mail: elia.dischiavi@ibbr.cnr.it

Scientific Committee

Ennio Del Giudice, Department of Translational Medicine, Section of Pediatrics, University of Naples Federico II
Carla Lucini, Department of Veterinary Medicine and Animal Production, University of Naples Federico II
Elia Di Schiavi, Institute of Biosciences and BioResources, IBBR Department of Biology, Agriculture and Food Science – CNR
Mauro Cataldi, Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II
Paolo Sordino, Stazione Zoologica A. Dohrn
Gaetano Terrone, Department of Translational Medicine, Section of Pediatrics, University of Naples Federico II
Rossella Di Giaimo, Department of Biology, University of Naples Federico II
Michele Pinelli, Telethon Institute of Genetics and medicine (TIGEM), Pozzuoli
Simona Paladino, Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II
Gennaro Piccialli, Department of Pharmacy, University of Naples Federico II
Maria Giuseppina Miano, Institute of Genetics and Biophysics Adriano Buzzati-Traverso, CNR
Alfonso Romano, Dipartimento di Pediatria dell'Università degli Studi di Napoli "Federico II"
Giuseppina Vitiello, Department of Translational Medicine, Section of Pediatrics, University of Naples Federico II
Andrea De Bartolomeis, Laboratory of Molecular and Translational Psychiatry- Department of Neuroscience- Reproductive Sciences and Odontostomatology, University of Naples Federico II
Carmela Bravaccio, Department of Translational Medicine, Section of Pediatrics, University of Naples Federico II
Maria Pia Riccio, Department of Maternal and Child Health, Child and Adolescent Neuropsychiatric Unit, Federico II University Hospital, Naples
Maurizio Taglialatela, Section of Pharmacology, Department of Neuroscience, University of Naples Federico II
Enrico Maria Surace, Department of Translational Medical Sciences (DiSMeT), University of Naples "Federico II", Italy

Thursday, April 8, 2021

Online seminar: "Dopamine related disorders: new models and prospective therapeutic approaches" by Damiana Leo

Dopamine related disorders: new models and prospective therapeutic approaches

Contacts

About

Scientific Committee

Search

NBG association

Past Editions

Menu

Patronage